Chronic myeloid leukemia (CML) is a slowly progressing disease of the blood and bone marrow. The disease usually occurs in middle-aged or elderly individuals and rarely occurs in children. In CML, an unusually large number of blood stem cells become granulocytes. These granulocytes, also called leukemia cells, are irregularly shaped and do not develop into healthy white blood cells. Eventually, they concentrate in the blood without leaving room for healthy cells, which can lead to infections, anemia, or bleeding. Typical signs of CML include fatigue, fever, night sweats, and weight loss (6). CML is due to a change in chromosome 22 (the Philadelphia chromosome, named after the place of discovery) of DNA in immature cells of the bone marrow. It turned out that there is a translocation, that is, a movement of a part of the DNA of the distal part, or long arms, of chromosome 22 to chromosome 9. The gene formed from the translocation is called the BCR-ABL gene from the c- ABL gene on chromosome 9 and BCR gene on chromosome 22. The BCR-ABL gene determines the production of a mutated protein that c...