I believe disease was a key factor if not the main factor in the depopulation of Native Americans in the Americas. Throughout time, there has always been inequality during the evolution of humanity. Throughout evolution, different cultures and races have progressed more rapidly and at a faster pace than others. The depopulation of Native Americans occurred because Europeans had better and more efficient supplies, as well as immunity to the diseases they brought with them. As Europeans traveled to the New World, they often brought with them domesticated animals as sources of food and food. livestock. When animals and humans live in close proximity, exposure to germs is very likely to occur. New diseases were brought by foreigners seeking fame and gold who killed many natives in the new lands. The natives had no chance against these new threats due to the lack of knowledge and means to cure themselves. Once Europeans discovered diseases as they landed in the New World, their journey only became easier as their competition was wiped out by the rapid spread. Microbes from Europe introduced new diseases and produced devastating epidemics that swept through native populations (Nichols 2008). The result of diseases brought with them, such as smallpox, was a demographic catastrophe that killed millions of people, weakened existing societies, and greatly aided the Spanish and Portuguese in their rapid and devastating conquest of existing American empires (Brinkley 2014). The interaction occurred with the arrival of whites and foreigners. The first and perhaps most profound result of this exchange was the im… middle of paper… problems are lost in history and cultural changes are immeasurable (Snipp 1989). The rapid spread of new diseases has caused the deaths of millions of people. Native Americans didn't stand a chance, as they had no cures or ways to fight these diseases. Works Cited Brinkley, Alan. The Unfinished Nation: A Concise History of the American People. New York: McGraw-Hill, 2014Diamond, Jared. Guns, germs and steel: the fate of human societies. New York: W. W. Norton & Company, 1999. Nichols, L. Roger. The American Indian: Past and Present. University of Oklahoma Press, Norman, University Publishing Division, 2008.Snipp, C. Matthew. American Indians: the first of this land. Russell Sage Foundation, 1989.Thornton, Russell. Holocaust and American Indian Survival: A Population History Since 1492. University of Oklahoma Press, Norman, University Publishing Division, 1987.